At least five people have been killed and over 20 injured in a motorway crash involving a coach near the eastern German city of Leipzig.
The FlixBus coach veered to the right on the busy A9 autobahn before falling on to its side.
The coach had left Berlin with two drivers and 53 passengers and was on its way to Nuremberg en route to Zurich, the company confirmed.
Officials in the state of Saxony said their thoughts were with the victims.
FlixBus, founded in Munich in 2011, runs a network of long-distance coach services in Europe, America and Asia.
The company said the accident had happened at around 10:00 (09:00 GMT) on the A9, the north-south motorway from Berlin to Munich. The 107 service bus was two hours into its southbound journey at the time of the crash at a junction near Leipzig/Halle Airport, to the north-west of the city.
Police told German media that no other vehicle was involved in the accident.
"The exact circumstances of the accident are not yet known," the company said in a statement, adding that the long-distance service was being run on behalf of FlixBus. "Our thoughts are with all those affected by this accident and their families."
Police said rescue helicopters and a large number of ambulances were immediately called to the scene.
Local hospitals were told to prepare for a major emergency. Both carriageways on the Autobahn were closed near the Schkeuditzer Kreuz interchange. Police said the rescue operation was expected to continue until the evening.
Coaches have crashed in the past on the A9 motorway near Leipzig, most recently in December. A woman was killed in a coach accident on the A9 in 2019, some 20km (12 miles) south of Wednesday's crash in the state of Saxony-Anhalt.
