- Another summer signing Cole Palmer leveled the score from the penalty spot in the 35th minute after Dejan Kulusevski had given Tottenham a sixth-minute lead.
- Spurs left-back Destiny Udogie was also sent off after receiving a second yellow card in the 55th minute.
Chelsea summer signing Nicholas Jackson scored his first hat-trick for the London-based club as the Blues beat nine-man Tottenham 4-1 at the Tottenham Hotspur Stadium on Monday night.
The Senegalese forward scored in the 75th, 94th and 97th minutes to become the first Chelsea player to score a hat-trick against Spurs since 2002.
Another summer signing Cole Palmer leveled the score from the penalty spot in the 35th minute after Dejan Kulusevski had given Tottenham a sixth-minute lead.
Christian Romero was punished for a crude challenge on compatriot Enzo Fernandez, and the Spurs defender was deservedly sent off in the aftermath.
Spurs left-back Destiny Udogie was also sent off after receiving a second yellow card in the 55th minute, giving Chelsea a numerical advantage.
Mauricio Pochettino made a winning return to Tottenham with Chelsea against his former club on a night of chaos and controversy.
The match saw five goals disallowed and a slew of VAR decisions in one of the Premier League's most frenetic encounters.
Spurs hopes of returning to the summit of the Premier League standings were extinguished in a spectacular, incident-packed game.
Tottenham saw Van de Ven and James Maddison suffer injuries while the suspension of Romero and Udogies leaves Spurs short of options considering the importance of the quartet.
The win lifted Chelsea to the top half of the table with 15 points after four wins, three draws and four losses.
Tottenham remain second on 26 points, a point behind leaders and defending champions Manchester City.
Tottenham faces Wolverhampton Wanderers on Saturday while Chelsea faces a litmus test against high-flying Man City at Stamford Bridge.