President William Ruto on Tuesday will hold the Cabinet meeting at the Kakamega State Lodge.
This will be the first time he will hold such a meeting in the Western Region.
The head of state will wrap up his tour in the region after launching several projects among them being an industrial park in Bungoma County.
This will also be the second time Ruto is chairing a cabinet meeting outside Nairobi.
The announcement was made by Deputy President Rigathi Gachagua.
While in the region, Ruto met several leaders who assured him of their support.
Prime Cabinet Secretary Musalia Mudavadi called on the Western Kenya region to appreciate the generosity of the President.
Mudavadi said the head of state has extended an olive branch to the people in the region and wants them to be part of his government.
“When we say we want a united Kenya and call for national unity and inclusivity, President Ruto is the best example of this. We have seen the key appointments he has given to the sons and daughters of Mulembe nation," he said.
"This does not mean that he has not done so for other regions, but it sends a message that the President has the interest of the people of Western at heart."
The Prime CS added that the region should fully support the Government's development agenda, saying they should reflect on the manifesto and promises made by President William Ruto for the benefit of the region.