- Several MOU, Foreign Affairs Cabinet Secretary Alfred Mutua said, will also be signed.
- "The visit is expected to boost trade and investment opportunities between our two countries," said Mutua.
Italian President Sergio Mattarella on Monday arrived in the country for a four-day official visit.
Matarella is expected to hold bilateral talks with President Ruto.
Several MoUs, Foreign Affairs Cabinet Secretary Alfred Mutua said, will also be signed.
"The visit is expected to boost trade and investment opportunities between our two countries," said Mutua.
In a post, Mutua added the visit will help promote the development of key sectors such as water, agriculture, and tourism in the country.
Mattarella is also set to hold a public lecture on climate change at the University of Nairobi.
State House announced the visit by Mattarella last month after a meeting between President Ruto and Italian Ambassador to Kenya Roberto Natali at the Statehouse, Nairobi.
The meeting, it said, would enhance cooperation between the two countries.
During the meeting, Ruto highlighted the significance of the Mattarella visit noting it is a high point in their relationship.
It is his sixth trip to the African continent.
He has already been to Cameroon, Ethiopia, Zambia, Mozambique and Angola.
In a program seen by the Star, the Italian President will proceed to the late President Jomo Kenyatta's mausoleum at the Parliament buildings where he will lay a wreath after the State House meeting.
He will be received by the Speakers of both Houses.
On Wednesday, Mattarella will be in Malindi where he will visit the "Luigi Broglio" Space Center.
Italian Space Agency President Giorgio Saccoccia, the Kenyan Space Agency director James Aruasa and defence CS Duale will accompany him.
On the same day, the president will also visit the Embassy in Nairobi.
On Thursday, Mattarella and his delegation will be at UON followed by a meeting at E4Impact accelerator.
E4Impact is an initiative launched in 2010 by ALTIS – Graduate School of Business and Society of Università Cattolica del Sacro Cuore, with the objective of supporting the start-up and growth of new businesses in Africa.
In 2015, E4Impact became a foundation thanks to the support of some leading Italian companies.
The program was launched by the Catholic University of the Sacred Heart of Milan with the E4Impact Foundation to help start-ups and African MSME enterprises.