Heavy rains last night caused flooding in parts of Accra, trapping some residents in their homes, submerging vehicles and destroying properties.
Hundreds of residents have been left homeless. The west of the capital, which is a low laying area, is worst affected.
The flooding has again exposed the poor drainage system in Accra.
Floods are very common in the capital and authorities say that the country requires around $700m (£531m) to fix the problem permanently.
The Ghana Meteorological Agency has warned of more heavy rains over the next two months.