Gor Mahia will play English Premier League side Everton at the Goodison Park in the UK in November.
The 6 November match is part of Kenyan betting firm SportPesa's sponsorship deal with Everton.
"The historic fixture will kick-off at 7pm and will mark the first occasion an East African club side has contested a match in the UK," Everton said in a statement.
The match is part of the SportPesa Trophy, which is contested by clubs in Kenya and Tanzania. Winners of the competition play Everton in the final.
Last year, Everton travelled to Tanzania for the inaugural SportPesa Super Cup and played Gor Mahia at the National Stadium in Tanzania.
The Kenyan betting company is Everton football club's main sponsor. It also sponsors Torino FC in Italy as well as Hull City and Southampton FC in England.
Since its inception in 2014, it has supported various sporting disciplines and teams at home and abroad.